Nature Communications (Aug 2021)

PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis

  • Thais G. Moreira,
  • Davide Mangani,
  • Laura M. Cox,
  • Jeffrey Leibowitz,
  • Eduardo. L. C. Lobo,
  • Mariana A. Oliveira,
  • Christian D. Gauthier,
  • Brenda N. Nakagaki,
  • Valerie Willocq,
  • Anya Song,
  • Lydia Guo,
  • David C. A. Lima,
  • Gopal Murugaiyan,
  • Oleg Butovsky,
  • Galina Gabriely,
  • Ana C. Anderson,
  • Rafael M. Rezende,
  • Ana Maria C. Faria,
  • Howard L. Weiner

DOI
https://doi.org/10.1038/s41467-021-25115-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell responses to prevent gut inflammation.