OncoTargets and Therapy (Oct 2020)
Ruxolitinib Plus Decitabine Effectively Treats Myelodysplastic Syndrome/Myeloproliferative Neoplasm, Unclassifiable, by Decreasing the Variant Allele Frequency of KRAS
Abstract
Shuna Luo,1 Xiaofei Xu,1 Xingnong Ye,1,2 Xiaoqiong Zhu,1 Cai Wu,1 Dan Chen,1 Jingxia Jin,1 Yan Zheng,1 Mengli Zheng,1 Jian Huang1,2 1Department of Hematology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, People’s Republic of China; 2Department of Hematology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Jian HuangDepartment of Hematology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, N1 Shangcheng Road, Yiwu, Zhejiang 322000, People’s Republic of ChinaTel +86 1 886 796 1032Fax +86 5 798 993 5555Email [email protected]: Myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U) is a subtype of MDS/MPN that exhibits a combination of the features of both MDS and MPN. To date, no curative treatment is available for MDS/MPN-U; however, previous studies have suggested a potential survival advantage for ruxolitinib and hypomethylating agents. We reported a case of a JAK2-negative but KRAS-positive MDS/MPN-U patient treated with ruxolitinib plus decitabine. After treatment, the patient’s clinical symptoms were moderated, and the size of the spleen and the peripheral blood cell counts were reduced. These effects might be due to the regimen’s ability to reduce STAT5 activation and upregulate microRNA-181c to downregulate the variant allele frequency (VAF) of KRAS.Keywords: myelodysplastic syndrome, myeloproliferative neoplasm, decitabine, ruxolitinib, KRAS
