Essential Oils Derived from <i>Cistus</i> Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition
Merieme Ledrhem,
Miku Nakamura,
Miyu Obitsu,
Kinue Hirae,
Jun Kameyama,
Hafida Bouamama,
Chemseddoha Gadhi,
Yoshinori Katakura
Affiliations
Merieme Ledrhem
Faculty of Sciences and Techniques, Cadi Ayyad Unversity, P.O. Box 549, Bd Elkhattabi, Marrakesh 40000, Morocco
Miku Nakamura
Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Miyu Obitsu
Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Kinue Hirae
Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Jun Kameyama
Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Hafida Bouamama
Faculty of Sciences and Techniques, Cadi Ayyad Unversity, P.O. Box 549, Bd Elkhattabi, Marrakesh 40000, Morocco
Chemseddoha Gadhi
Faculty of Sciences Semlalia, Cadi Ayyad Unversity, P.O. Box 2390, Bd My Abdellah, Marrakesh 40000, Morocco
Yoshinori Katakura
Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Cistus L. is a genus of dicotyledonous perennial herbaceous plants. Cistus species have been commonly used in folk medicine in the Mediterranean region. In the present study, the biological activities of essential oils derived from Cistus species (Cistus laurifolius, C. monspeliensis, C. creticus, and C. salviifolius) were evaluated. Essential oils derived from C. laurifolius and C. monspeliensis were found to augment the expression of SIRT1, an anti-aging gene, in the normal culture of HaCaT cells. Furthermore, these essential oils increased the number and size of mitochondria and augmented their activity. These effects were thought to be caused by the up- and downregulated expression of MITOL and Drp1 in HaCaT cells, respectively, in response to the essential oil treatment. In addition, these essential oils were found to attenuate ultraviolet-B-induced mitochondrial damage and cellular senescence in HaCaT cells. These findings indicate that essential oils derived from C. laurifolius and C. monspeliensis may inhibit skin aging through mitochondrial regulation via SIRT1 activation.
