Diagnostic predictive values of the Hain genotype MTBDRsl assay in mycobacterial strains isolated from Sudan

Abstract

INTRODUCTION: Hain GenoType MTBDRsl is nucleic acid amplification assay based on reverse hybridization with specific oligonucleotide probes on nitrocellulose strips. MTBDRsl identifies M. tuberculosis complex and detects resistance to fluoroquinolone, second line injectable drugs and ethambutol evident as mutations of gyrA, rrs and embB genes respectively. This study aimed to evaluate the diagnostic performance of the Hain GenoType MTBDRsl Assay using 1% proportion method on LJ medium as gold standard.

Keywords

• hain genotype mtbdrsl
• mdr
• xdr
• sudan
• tuberculosis