METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

Lijun Wang; Jiaqi Wang; Pujiao Yu; Jingyi Feng; Gui-e Xu; Xuan Zhao; Tianhui Wang; H. Immo Lehmann; Guoping Li; Joost P. G. Sluijter; Junjie Xiao

doi:10.1038/s41467-022-34434-y

Nature Communications (Nov 2022)

METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

Lijun Wang,
Jiaqi Wang,
Pujiao Yu,
Jingyi Feng,
Gui-e Xu,
Xuan Zhao,
Tianhui Wang,
H. Immo Lehmann,
Guoping Li,
Joost P. G. Sluijter,
Junjie Xiao

Affiliations

Lijun Wang: Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University
Jiaqi Wang: Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University
Pujiao Yu: Department of Cardiology, Shanghai Tongji hospital, Tongji University School of Medicine
Jingyi Feng: Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University
Gui-e Xu: Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University
Xuan Zhao: Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University
Tianhui Wang: Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University
H. Immo Lehmann: Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School
Guoping Li: Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School
Joost P. G. Sluijter: Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht
Junjie Xiao: Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University

DOI: https://doi.org/10.1038/s41467-022-34434-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

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The benefit of regular exercise on the heart has been well documented but the role of RNA m6A modification in exercise-induced cardiac remodelling remains largely unknown. In this study, the authors report that METTL14 plays an important role in RNA m6A modification in exercise-induced physiological cardiac hypertrophy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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