Communications Biology (Jan 2023)

A design of experiments screen reveals that Clostridium novyi-NT spore germinant sensing is stereoflexible for valine and its analogs

  • Ajitha Sundaresan,
  • Mai Le Ngoc,
  • Marvell Ung Wew,
  • Varsha Ramkumar,
  • Prahlad Raninga,
  • Rongji Sum,
  • Ian Cheong

DOI
https://doi.org/10.1038/s42003-023-04496-9
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 15

Abstract

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A screen for germination of Clostridium novyi-NT spores reveals that germinant sensing of this tumor-destructive anaerobic bacterium is stereoflexible for valine and its analogs and identifies co-germinants to improve germination efficacy in tumors.