Pharmaceuticals (Dec 2023)

Nuclear Cross-Section of Proton-Induced Reactions on Enriched <sup>48</sup>Ti Targets for the Production of Theranostic <sup>47</sup>Sc Radionuclide, <sup>46c</sup>Sc, <sup>44m</sup>Sc, <sup>44g</sup>Sc, <sup>43</sup>Sc, and <sup>48</sup>V

  • Liliana Mou,
  • Lucia De Dominicis,
  • Sara Cisternino,
  • Hanna Skliarova,
  • Matteo Campostrini,
  • Valentino Rigato,
  • Laura De Nardo,
  • Laura Meléndez-Alafort,
  • Juan Esposito,
  • Férid Haddad,
  • Gaia Pupillo

DOI
https://doi.org/10.3390/ph17010026
Journal volume & issue
Vol. 17, no. 1
p. 26

Abstract

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The cross-sections of the 48Ti(p,x)47Sc, 46cSc, 44mSc, 44gSc, 43Sc, and 48V nuclear reactions were measured from 18 to 70 MeV, with particular attention to 47Sc production. Enriched 48Ti powder was deposited on an aluminum backing and the obtained targets were characterized via elastic backscattering spectroscopy at the INFN-LNL. Targets were exposed to low-intensity proton irradiation using the stacked-foils technique at the ARRONAX facility. Activated samples were measured using γ-spectrometry; the results were compared with the data int he literature and the theoretical TALYS-based values. A regular trend in the new values obtained from the different irradiation runs was noted, as well as a good agreement with the literature data, for all the radionuclides of interest: 47Sc, 46cSc, 44mSc, 44gSc, 43Sc, and 48V. 47Sc production was also discussed, considering yield and radionuclidic purity, for different 47Sc production scenarios.

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