Relation of complete blood count parameters and derivatives with radiologic staging of knee osteoarthritis

Abstract

Purpose: In this study, the relationship between radiologic progression and complete blood count parameters and derivatives, which have appeared as biomarkers for systemic inflammation in recent years, were evaluated in patients with knee osteoarthritis (OA). Materials and Methods: This retrospective study included 209 consecutive patients 40 to 80 years of age diagnosed with knee OA according to 2010 American College of Rheumatology clinical criteria. Participants’ demographic characteristics, complete blood parameters and derivatives were recorded. Blood platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and monocyte to neutrophil ratio (MNR) levels were calculated. Results: The majority of patients with high-grade knee OA were determined to be females of an advanced agewith higher patellar tendon length (PTL). Their leukocyte (WBC), neutrophil, and NLR levels were significantly higher than others. When we compared this group of patients to four groups (grades 1-4), advanced age, female gender, PTL, Q angle, WBC, neutrophils, mean platelet volume (MPV), and NLR were significantly higher in patients with grade 4 knee OA. Conclusion: In advanced knee OA, patellofemoral Q angle and PTL increased along with serum WBC, neutrophil, NLR, and MPV levels while RBC, Hb, lymphocyte, monocyte, basophil, and eosinophil levels were reduced. In the future, these parameters may be used as a guide to OA progression.

Keywords

• osteoarthritis
• inflammation
• inflammatuar markers
• complete blood count
• neutrophil to lymphocyte ratio
• osteoartrit
• inflamasyon
• inflamatuar belirteçler
• tam kan sayımı
• nötrofil lenfosit oranı