New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB
Tu Rong-Hui,
Wang Dong-Xiao,
Zhong Guo-Qiang,
Meng Jian-Jun,
Wen Hong,
Jie-Feng,
Bi Qi,
He Yan
Affiliations
Tu Rong-Hui
Department of Geriatric Cardiology, First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi, China
Wang Dong-Xiao
Department of Cardiology, First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China
Zhong Guo-Qiang
Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention, First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, China
Meng Jian-Jun
Department of Geriatric Cardiology, First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi, China
Wen Hong
Department of Geriatric Cardiology, First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi, China
Jie-Feng
School of Pharmaceutical Science, Guangxi Medical University, Nanning, 530021, Guangxi, China
Bi Qi
Department of Cardiology, First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China
He Yan
Department of Geriatric Cardiology, First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi, China
Activation of the complement component 5a (C5a) and nuclear factor κB (NF-κB) signaling is an important feature of myocardial ischemia/reperfusion (I/R) injury and recent studies show that morphine postconditioning (MP) attenuates the myocardial injury. However, the mediating cardioprotective mechanisms remain unclear. The present study explores the role and interaction of heat shock protein 90 (HSP90), Akt, C5a, and NF-κB in MP-induced cardioprotection.
