Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling

Lauriane Pous; Sachin S. Deshpande; Suvra Nath; Szilvia Mezey; Subash C. Malik; Sebastian Schildge; Christian Bohrer; Könül Topp; Dietmar Pfeifer; Francisco Fernández-Klett; Soroush Doostkam; Dennis K. Galanakis; Verdon Taylor; Katerina Akassoglou; Christian Schachtrup

doi:10.1038/s41467-020-14466-y

Nature Communications (Jan 2020)

Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling

Lauriane Pous,
Sachin S. Deshpande,
Suvra Nath,
Szilvia Mezey,
Subash C. Malik,
Sebastian Schildge,
Christian Bohrer,
Könül Topp,
Dietmar Pfeifer,
Francisco Fernández-Klett,
Soroush Doostkam,
Dennis K. Galanakis,
Verdon Taylor,
Katerina Akassoglou,
Christian Schachtrup

Affiliations

Lauriane Pous: Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg
Sachin S. Deshpande: Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg
Suvra Nath: Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg
Szilvia Mezey: Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg
Subash C. Malik: Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg
Sebastian Schildge: Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg
Christian Bohrer: Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg
Könül Topp: Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg
Dietmar Pfeifer: Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, University of Freiburg
Francisco Fernández-Klett: Department of Neuropsychiatry & Laboratory of Molecular Psychiatry, Charité – Universitätsmedizin Berlin
Soroush Doostkam: Institute of Neuropathology, University Medical Center Freiburg, University of Freiburg
Dennis K. Galanakis: Department of Pathology, State University of New York
Verdon Taylor: Department of Biomedicine, Embryology and Stem Cell Biology, University of Basel, Mattenstrasse 28
Katerina Akassoglou: Gladstone Institutes
Christian Schachtrup: Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg

DOI: https://doi.org/10.1038/s41467-020-14466-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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The molecular mechanisms regulating adult neural stem/progenitor cell differentiation following damage of the central nervous system are unclear. Here, the authors show that fibrinogen is a regulator of the adult neural stem/progenitor cell switch from neurogenesis to astrogenesis in a model of stroke

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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