Molecules
(Mar 2019)
General, Practical and Selective Oxidation Protocol for CF<sub>3</sub>S into CF<sub>3</sub>S(O) Group
Liubov V. Sokolenko,
Raisa K. Orlova,
Andrey A. Filatov,
Yurii L. Yagupolskii,
Emmanuel Magnier,
Bruce Pégot,
Patrick Diter
Affiliations
Liubov V. Sokolenko
Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmans’ka Str. 5, 02094 Kyiv, Ukraine
Raisa K. Orlova
Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmans’ka Str. 5, 02094 Kyiv, Ukraine
Andrey A. Filatov
Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmans’ka Str. 5, 02094 Kyiv, Ukraine
Yurii L. Yagupolskii
Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmans’ka Str. 5, 02094 Kyiv, Ukraine
Emmanuel Magnier
Bâtiment Lavoisier, Université de Versailles-Saint-Quentin, 45 avenue des Etats-Unis, 78035 Versailles, France
Bruce Pégot
Bâtiment Lavoisier, Université de Versailles-Saint-Quentin, 45 avenue des Etats-Unis, 78035 Versailles, France
Patrick Diter
Bâtiment Lavoisier, Université de Versailles-Saint-Quentin, 45 avenue des Etats-Unis, 78035 Versailles, France
DOI
https://doi.org/10.3390/molecules24071249
Journal volume & issue
Vol. 24,
no. 7
Abstract
Read online
A simple and efficient protocol for the oxidation of trifluoromethyl, mono- and difluoromethyl sulfides to the corresponding sulfoxides without over-oxidation to sulfones, using TFPAA prepared in situ from trifluoroacetic acid and 15% H2O2 aqueous solution was developed. The methodology is suitable for a wide range of aromatic and aliphatic substrates in milligram and multigram scales.
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