Role of Circular RNAs in Atherosclerosis through Regulation of Inflammation, Cell Proliferation, Migration, and Apoptosis: Focus on Atherosclerotic Cerebrovascular Disease
Zheng Zhang,
Lingfei Li,
Huanqing Shi,
Biao Chen,
Xiaoqin Li,
Yuyao Zhang,
Fei Liu,
Wan Wei,
Yongji Zhou,
Keqin Liu,
Wenqing Xia,
Xin Gu,
Jinyu Huang,
Sheng Tu,
Congguo Yin,
Anwen Shao,
Lin Jiang
Affiliations
Zheng Zhang
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
Lingfei Li
Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Huanqing Shi
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
Biao Chen
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
Xiaoqin Li
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
Yuyao Zhang
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
Fei Liu
Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Wan Wei
Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Yongji Zhou
Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Keqin Liu
Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Wenqing Xia
Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Xin Gu
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
Jinyu Huang
Department of Cardiology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
Sheng Tu
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
Congguo Yin
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
Anwen Shao
Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Lin Jiang
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China
Atherosclerosis (AS) is a disease dangerous to human health and the main pathological cause of ischemic cardiovascular diseases. Although its pathogenesis is not fully understood, numerous basic and clinical studies have shown that AS is a chronic inflammatory disease existing in all stages of atherogenesis. It may be a common link or pathway in the pathogenesis of multiple atherogenic factors. Inflammation is associated with AS complications, such as plaque rupture and ischemic cerebral infarction. In addition to inflammation, apoptosis plays an important role in AS. Apoptosis is a type of programmed cell death, and different apoptotic cells have different or even opposite roles in the process of AS. Unlike linear RNA, circular RNA (circRNA) a covalently closed circular non-coding RNA, is stable and can sponge miRNA, which can affect the stages of AS by regulating downstream pathways. Ultimately, circRNAs play very important roles in AS by regulating inflammation, apoptosis, and some other mechanisms. The study of circular RNAs can provide new ideas for the prediction, prevention, and treatment of AS.
