CP-673451, a platelet-derived growth-factor receptor inhibitor, suppresses lung cancer cell proliferation and migration

Abstract

Yuling Xi,1 Ming Chen,1 Xinmin Liu,1 Zhongmin Lu,1 Yi Ding,1 Datong Li2 1First Affiliated Hospital of Xinxiang Medical University, 2Hualan Vaccine, Xinxiang, People's Republic of China Abstract: Lung cancer is the leading cause of cancer mortality in the world. Although some advances in lung cancer therapy have been made, patient survival is still poor. The platelet-derived growth factor receptors (PDGFRs) and their ligands play critical roles in the regulation of many cancer cell processes, including cell survival and cell motility. Herein, we investigate the anticancer activities of CP-673451, a potent selective inhibitor of PDGFR kinase, in non-small-cell lung cancer (NSCLC) therapy. We found that CP-673451 is effective at suppressing cell viability, inducing cell apoptosis, and inhibiting cell migration and invasion by suppressing the PDGFR downstream signaling pathway in NSCLC cells. Furthermore, CP-673451 is effective at suppressing NSCLC tumor growth in vivo. In summary, our studies suggest that CP-673451 might be a promising therapeutic compound for NSCLC. Keywords: CP-673451, platelet-derived growth factor receptors (PDGFRs), lung cancer, proliferation, migration