Frontiers in Pediatrics (Jul 2022)
The Cellular and Molecular Effects of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia
- Oluyinka O. Olutoye II,
- Oluyinka O. Olutoye II,
- Walker D. Short,
- Walker D. Short,
- Jamie Gilley,
- J. D. Hammond II,
- Michael A. Belfort,
- Michael A. Belfort,
- Timothy C. Lee,
- Timothy C. Lee,
- Timothy C. Lee,
- Alice King,
- Alice King,
- Alice King,
- Jimmy Espinoza,
- Jimmy Espinoza,
- Luc Joyeux,
- Luc Joyeux,
- Luc Joyeux,
- Krithika Lingappan,
- Jason P. Gleghorn,
- Sundeep G. Keswani,
- Sundeep G. Keswani,
- Sundeep G. Keswani
Affiliations
- Oluyinka O. Olutoye II
- Division of Pediatric Surgery, Department of Surgery, Texas Children's Hospital, Houston, TX, United States
- Oluyinka O. Olutoye II
- Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, United States
- Walker D. Short
- Division of Pediatric Surgery, Department of Surgery, Texas Children's Hospital, Houston, TX, United States
- Walker D. Short
- Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, United States
- Jamie Gilley
- Division of Neonatology, Department of Pediatrics, Texas Children's Hospital, Houston, TX, United States
- J. D. Hammond II
- Division of Neonatology, Department of Pediatrics, Texas Children's Hospital, Houston, TX, United States
- Michael A. Belfort
- Texas Children's Fetal Center, Baylor College of Medicine, Houston, TX, United States
- Michael A. Belfort
- Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, United States
- Timothy C. Lee
- Division of Pediatric Surgery, Department of Surgery, Texas Children's Hospital, Houston, TX, United States
- Timothy C. Lee
- Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, United States
- Timothy C. Lee
- Texas Children's Fetal Center, Baylor College of Medicine, Houston, TX, United States
- Alice King
- Division of Pediatric Surgery, Department of Surgery, Texas Children's Hospital, Houston, TX, United States
- Alice King
- Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, United States
- Alice King
- Texas Children's Fetal Center, Baylor College of Medicine, Houston, TX, United States
- Jimmy Espinoza
- Texas Children's Fetal Center, Baylor College of Medicine, Houston, TX, United States
- Jimmy Espinoza
- Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, United States
- Luc Joyeux
- Division of Pediatric Surgery, Department of Surgery, Texas Children's Hospital, Houston, TX, United States
- Luc Joyeux
- Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, United States
- Luc Joyeux
- Texas Children's Fetal Center, Baylor College of Medicine, Houston, TX, United States
- Krithika Lingappan
- Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States
- Jason P. Gleghorn
- Department of Biomedical Engineering, University of Delaware, Newark, DE, United States
- Sundeep G. Keswani
- Division of Pediatric Surgery, Department of Surgery, Texas Children's Hospital, Houston, TX, United States
- Sundeep G. Keswani
- Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, United States
- Sundeep G. Keswani
- Texas Children's Fetal Center, Baylor College of Medicine, Houston, TX, United States
- DOI
- https://doi.org/10.3389/fped.2022.925106
- Journal volume & issue
-
Vol. 10
Abstract
Congenital diaphragmatic hernia (CDH) is a complex disease associated with pulmonary hypoplasia and pulmonary hypertension. Great strides have been made in our ability to care for CDH patients, specifically in the prenatal improvement of lung volume and morphology with fetoscopic endoluminal tracheal occlusion (FETO). While the anatomic effects of FETO have been described in-depth, the changes it induces at the cellular and molecular level remain a budding area of CDH research. This review will delve into the cellular and molecular effects of FETO in the developing lung, emphasize areas in which further research may improve our understanding of CDH, and highlight opportunities to optimize the FETO procedure for improved postnatal outcomes.
Keywords
- congenital diaphragmatic hernia (CDH)
- tracheal occlusion (TO)
- FETO
- pulmonary hypoplasia
- pulmonary hypertension
- pulmonary development
