SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
Maria Clara Saad Menezes,
Diego Vinicius Santinelli Pestana,
Gustavo Rosa Gameiro,
Luiz Fernando Ferraz da Silva,
Ėlodie Baron,
Jean-Jacques Rouby,
José Otavio Costa Auler Jr
Affiliations
Maria Clara Saad Menezes
Anesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
Diego Vinicius Santinelli Pestana
Anesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
Gustavo Rosa Gameiro
Anesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
Luiz Fernando Ferraz da Silva
Department of Pathology, Faculdade de Medicina, Universidade de Sao Paulo
Ėlodie Baron
Multidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance-Publique-Hôpitaux-de-Paris, Sorbonne University
Jean-Jacques Rouby
Multidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance-Publique-Hôpitaux-de-Paris, Sorbonne University
José Otavio Costa Auler Jr
Anesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
Abstract The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability.
