Nature Communications (May 2021)
Ultraviolet light-induced collagen degradation inhibits melanoma invasion
- Timothy Budden,
- Caroline Gaudy-Marqueste,
- Andrew Porter,
- Emily Kay,
- Shilpa Gurung,
- Charles H. Earnshaw,
- Katharina Roeck,
- Sarah Craig,
- Víctor Traves,
- Jean Krutmann,
- Patricia Muller,
- Luisa Motta,
- Sara Zanivan,
- Angeliki Malliri,
- Simon J. Furney,
- Eduardo Nagore,
- Amaya Virós
Affiliations
- Timothy Budden
- Skin Cancer and Ageing Lab, Cancer Research UK Manchester Institute, The University of Manchester
- Caroline Gaudy-Marqueste
- Department of Dermatology and Skin Cancers, Aix-Marseille University
- Andrew Porter
- Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park
- Emily Kay
- Institute of Cancer Sciences, University of Glasgow
- Shilpa Gurung
- Skin Cancer and Ageing Lab, Cancer Research UK Manchester Institute, The University of Manchester
- Charles H. Earnshaw
- Skin Cancer and Ageing Lab, Cancer Research UK Manchester Institute, The University of Manchester
- Katharina Roeck
- Skin Cancer and Ageing Lab, Cancer Research UK Manchester Institute, The University of Manchester
- Sarah Craig
- Skin Cancer and Ageing Lab, Cancer Research UK Manchester Institute, The University of Manchester
- Víctor Traves
- Department of Dermatology, Institut Valencià Oncologia
- Jean Krutmann
- IUF – Leibniz Research Institute of Environmental Medicine
- Patricia Muller
- Tumour Suppressors Lab, Cancer Research UK Manchester Institute, The University of Manchester
- Luisa Motta
- Department of Histopathology, Salford Royal NHS Foundation Trust, The University of Manchester
- Sara Zanivan
- Institute of Cancer Sciences, University of Glasgow
- Angeliki Malliri
- Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park
- Simon J. Furney
- Genomic Oncology Research Group, Department of Physiology and Medical Physics, Royal College of Surgeons in
- Eduardo Nagore
- Department of Dermatology, Institut Valencià Oncologia
- Amaya Virós
- Skin Cancer and Ageing Lab, Cancer Research UK Manchester Institute, The University of Manchester
- DOI
- https://doi.org/10.1038/s41467-021-22953-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Ultraviolet radiation (UVR) increases melanoma incidence. Here, the authors report that UVR-damaged dermal fibroblasts upregulate MMP1 to degrade collagen which inhibits melanoma invasion and that aged primary melanomas in skin with degraded collagen have a better prognosis, while new collagen synthesis restores invasion and leads to death.
