Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

Silvia Basilico; Xiaonan Wang; Alison Kennedy; Konstantinos Tzelepis; George Giotopoulos; Sarah J. Kinston; Pedro M. Quiros; Kim Wong; David J. Adams; Larissa S. Carnevalli; Brian J. P. Huntly; George S. Vassiliou; Fernando J. Calero-Nieto; Berthold Göttgens

doi:10.1038/s41467-020-15220-0

Nature Communications (Mar 2020)

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

Silvia Basilico,
Xiaonan Wang,
Alison Kennedy,
Konstantinos Tzelepis,
George Giotopoulos,
Sarah J. Kinston,
Pedro M. Quiros,
Kim Wong,
David J. Adams,
Larissa S. Carnevalli,
Brian J. P. Huntly,
George S. Vassiliou,
Fernando J. Calero-Nieto,
Berthold Göttgens

Affiliations

Silvia Basilico: Wellcome and MRC Cambridge Stem Cell Institute and University of Cambridge Department of Haematology, Jeffrey Cheah Biomedical Centre
Xiaonan Wang: Wellcome and MRC Cambridge Stem Cell Institute and University of Cambridge Department of Haematology, Jeffrey Cheah Biomedical Centre
Alison Kennedy: Wellcome and MRC Cambridge Stem Cell Institute and University of Cambridge Department of Haematology, Jeffrey Cheah Biomedical Centre
Konstantinos Tzelepis: Wellcome Trust Sanger Institute
George Giotopoulos: Wellcome and MRC Cambridge Stem Cell Institute and University of Cambridge Department of Haematology, Jeffrey Cheah Biomedical Centre
Sarah J. Kinston: Wellcome and MRC Cambridge Stem Cell Institute and University of Cambridge Department of Haematology, Jeffrey Cheah Biomedical Centre
Pedro M. Quiros: Wellcome Trust Sanger Institute
Kim Wong: Wellcome Trust Sanger Institute
David J. Adams: Wellcome Trust Sanger Institute
Larissa S. Carnevalli: Oncology, AstraZeneca
Brian J. P. Huntly: Wellcome and MRC Cambridge Stem Cell Institute and University of Cambridge Department of Haematology, Jeffrey Cheah Biomedical Centre
George S. Vassiliou: Wellcome and MRC Cambridge Stem Cell Institute and University of Cambridge Department of Haematology, Jeffrey Cheah Biomedical Centre
Fernando J. Calero-Nieto: Wellcome and MRC Cambridge Stem Cell Institute and University of Cambridge Department of Haematology, Jeffrey Cheah Biomedical Centre
Berthold Göttgens: Wellcome and MRC Cambridge Stem Cell Institute and University of Cambridge Department of Haematology, Jeffrey Cheah Biomedical Centre

DOI: https://doi.org/10.1038/s41467-020-15220-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The oncogene MLL is frequently translocated in leukemia, resulting in oncogenic fusion proteins. Here, the authors report a temporally controlled mouse model of MLL-ENL driven leukemia AND identify therapeutic targets associated with early MLL-ENL driven leukaemogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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