Levels of Relevant Inflammatory Factors and Oxidative Stress Markers in Alcoholic Myopathy: a Meta-analysis

Abstract

Background Alcoholism can lead to alcoholic myopathy. Although there are over ten biomarkers used to evaluate this disease, their diagnostic value remains controversial. Objective To systematically evaluate the effects of alcoholic myopathy on levels of relevant inflammatory factors and oxidative stress markers. Methods The VIP Database for Chinese Technical Periodicals, Wanfang Data Knowledge Service Platform, China National Knowledge Infrastructure, Web of Science, PubMed, Embase and Cochrane Library databases were searched for animal intervention studies on inflammatory factors and oxidative stress markers in alcoholic myopathy from February 1, 1990 to August 31, 2021 to retrieve. RevMan 5.4.1 was used for Meta-analysis. Outcome measures included reduced glutathione (GSH) and malondialdehyde (MDA) levels as well as the mRNA expression levels of insulin-like growth factor 1 (IGF-1) and interleukin 6 (IL-6) . Results Ultimately, 17 animal interventionstudies were included, and the results of Meta-analysis showed that the levels of IGF-1 mRNA expression〔SMD=-3.09, 95%CI (-5.75, -0.43) , P=0.02〕and GSH levels〔SMD=-4.20, 95%CI (-6.24, -2.17) , P<0.000 01〕in the experimental group were lower than those in the control group. The levels of IL-6 mRNA expression〔SMD=3.75, 95%CI (2.93, 4.57) , P<0.000 01〕and MDA levels〔SMD=0.97, 95%CI (0.64, 1.29) , P<0.000 01〕were higher in the experimental group than those in the control group. Conclusion Animals with alcoholic myopathy show decreased IGF-1 mRNA expression and GSH levels but increased IL-6 mRNA expression and MDA levels.

Keywords

• myopathy|chronic alcoholic myopathy|oxidative stress|inflammatory factor infiltration|systematic evaluation|meta analysis