Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking

Pasquale Cervero; Christiane Wiesner; Anais Bouissou; Renaud Poincloux; Stefan Linder

doi:10.1038/s41467-018-02904-x

Nature Communications (Feb 2018)

Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking

Pasquale Cervero,
Christiane Wiesner,
Anais Bouissou,
Renaud Poincloux,
Stefan Linder

Affiliations

Pasquale Cervero: Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Eppendorf
Christiane Wiesner: Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Eppendorf
Anais Bouissou: Institut de Pharmacologie et Biologie Structurale, IPBS, CNRS, UPS, Université de Toulouse
Renaud Poincloux: Institut de Pharmacologie et Biologie Structurale, IPBS, CNRS, UPS, Université de Toulouse
Stefan Linder: Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Eppendorf

DOI: https://doi.org/10.1038/s41467-018-02904-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 19

Abstract

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The actomyosin cytoskeleton plays an important role in polarised cell migration. Here the authors identify lymphocyte-specific protein (LSP)-1 as a regulator of actomyosin contractility in macrophages, by competing with supervillin for myosin IIA activators acting specifically on the β-actin isoform.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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