Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids
Alexandra Németh-Rieder,
Péter Keglevich,
Attila Hunyadi,
Ahmed Dhahir Latif,
István Zupkó,
László Hazai
Affiliations
Alexandra Németh-Rieder
Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary
Péter Keglevich
Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary
Attila Hunyadi
Institute of Pharmacognosy, University of Szeged, Eötvös u. 6., H-6720 Szeged, Hungary
Ahmed Dhahir Latif
Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös Str. 6, H-6720 Szeged, Hungary
István Zupkó
Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös Str. 6, H-6720 Szeged, Hungary
László Hazai
Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary
Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hybrids were investigated on 60 cell lines of 9 common cancer types (NCI60) in vitro as antitumor agents. Some of them proved to have a significant antiproliferative effect.
