PBAT hollow porous microfibers prepared via electrospinning and their functionalization for potential peptide release

Yufei Liu; Long Yang; Guijing Chen; Zhentao Liu; Tao Lu; Yong Yang; Jia Yu; Dongdong Kang; Wei Yan; Min He; Shuhao Qin; Jie Yu; Chuan Ye; Heng Luo

Materials & Design (Sep 2021)

PBAT hollow porous microfibers prepared via electrospinning and their functionalization for potential peptide release

Yufei Liu,
Long Yang,
Guijing Chen,
Zhentao Liu,
Tao Lu,
Yong Yang,
Jia Yu,
Dongdong Kang,
Wei Yan,
Min He,
Shuhao Qin,
Jie Yu,
Chuan Ye,
Heng Luo

Affiliations

Yufei Liu: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang 550014, China
Long Yang: Department of Orthopaedics, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China; National Local Joint Engineering Laboratory of Cell Engineering and Biomedicine, Guiyang 550004, China
Guijing Chen: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang 550014, China
Zhentao Liu: School of Chemistry and Materials, Guiyang University, Guiyang 550005, China
Tao Lu: Department of Orthopaedics, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China; National Local Joint Engineering Laboratory of Cell Engineering and Biomedicine, Guiyang 550004, China
Yong Yang: Department of Orthopaedics, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China; National Local Joint Engineering Laboratory of Cell Engineering and Biomedicine, Guiyang 550004, China
Jia Yu: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
Dongdong Kang: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang 550014, China
Wei Yan: School of Chemistry and Materials, Guiyang University, Guiyang 550005, China
Min He: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China
Shuhao Qin: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang 550014, China
Jie Yu: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang 550014, China; Corresponding authors at: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China (J. Yu). Department of Orthopaedics, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China (C. Ye).
Chuan Ye: Department of Orthopaedics, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China; National Local Joint Engineering Laboratory of Cell Engineering and Biomedicine, Guiyang 550004, China; Corresponding authors at: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China (J. Yu). Department of Orthopaedics, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China (C. Ye).
Heng Luo: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; Corresponding authors at: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China (J. Yu). Department of Orthopaedics, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China (C. Ye).

Journal volume & issue: Vol. 207
p. 109880

Abstract

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Although microfiber (MF) loaded polypeptides have been widely studied in the field of medicine, load control and slow release remain significant challenges. Herein, polybutylene adipate terephthalate (PBAT) hollow porous MFs (HPMFs) were prepared by improving and regulating the groups and structures of the MFs to address these challenges. The capacity of the HPMFs for the loading of polypeptide can be improved. Measurements involving the use of X-ray photoelectron, energy-dispersive, and ultraviolet (UV) spectroscopies in conjunction with scanning electron microscopy measurements showed that the amount of polypeptide (arginylglycylaspartic acid, RGD) loaded on the HPMFs was significantly higher than that loaded on the MFs. Animal cell experiments revealed that PBAT grafted MAH has good bioactivity. By loading RGD onto HPMFs and MFs, RGD@HPMFs and RGD@MFs were obtained. A study on HeLa and A549 cancer cells showed that the inhibition rates of RGD@HPMFs were higher than that of RGD@MFs by 14.1% and 6.9%, respectively. The results obtained herein show that HPMF scaffold preparation by improving the material groups and regulating the structure of MFs can address the challenges associated with control of the load and sustained release of polypeptides and other drugs.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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