Interferon status as a method of determination of nonspecific biomarkers of human immunopathology

Abstract

For more than 60 years, the study of interferons (IFN) system has continued, as a complex network system. IFNs of 3 types are discovered: I (α/β), II (ƴ), III (λ), their interrelations, mechanisms of action, functional diversity are investigated. The practical way out of the study of the functional capacity of human peripheral blood leukocytes to produce IFN was the method of determining the interferon status, which allows to judge the immunoreactivity of the organism, to detect the sensitivity of blood cells to immunoac-tive drugs and makes it possible to determine the tactics of treatment in different forms of pathology and predict the outcome of the disease. An improved method of IFN status has been proposed and scientifically justified, the indicators of which can now be considered as characteristics of nonspecific biomarkers of human immunopathology.

Keywords

• interferons i (α/β)
• ii (ƴ)
• iii (λ) types
• interferon status
• improved methodology
• nonspecific biomarkers
• human immunopathology