Construction and experimental validation of a signature for predicting prognosis and immune infiltration analysis of glioma based on disulfidptosis-related lncRNAs

Youwei Guo; Youwei Guo; Zhipeng Jiang; Zhipeng Jiang; Quan Chen; Quan Chen; Dongcheng Xie; Dongcheng Xie; Yi Zhou; Yi Zhou; Wen Yin; Wen Yin; Zihan Wang; Zihan Wang; Binbin Wang; Caiping Ren; Caiping Ren; Xingjun Jiang; Xingjun Jiang

doi:10.3389/fimmu.2023.1291385

Frontiers in Immunology (Nov 2023)

Construction and experimental validation of a signature for predicting prognosis and immune infiltration analysis of glioma based on disulfidptosis-related lncRNAs

Youwei Guo,
Youwei Guo,
Zhipeng Jiang,
Zhipeng Jiang,
Quan Chen,
Quan Chen,
Dongcheng Xie,
Dongcheng Xie,
Yi Zhou,
Yi Zhou,
Wen Yin,
Wen Yin,
Zihan Wang,
Zihan Wang,
Binbin Wang,
Caiping Ren,
Caiping Ren,
Xingjun Jiang,
Xingjun Jiang

Affiliations

Youwei Guo: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Youwei Guo: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Zhipeng Jiang: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Zhipeng Jiang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Quan Chen: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Quan Chen: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Dongcheng Xie: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Dongcheng Xie: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Yi Zhou: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Yi Zhou: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Wen Yin: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Wen Yin: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Zihan Wang: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Zihan Wang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Binbin Wang: Department of Neurosurgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China
Caiping Ren: Cancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Caiping Ren: National Health Commission (NHC) Key Laboratory of Carcinogenesis and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medical Science, Central South University, Changsha, Hunan, China
Xingjun Jiang: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
Xingjun Jiang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China

DOI: https://doi.org/10.3389/fimmu.2023.1291385
Journal volume & issue: Vol. 14

Abstract

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BackgroundsDisulfidptosis, a newly discovered mechanism of programmed cell death, is believed to have a unique role in elucidating cancer progression and guiding cancer therapy strategies. However, no studies have yet explored this mechanism in glioma.MethodsWe downloaded data on glioma patients from online databases to address this gap. Subsequently, we identified disulfidptosis-related genes from published literature and verified the associated lncRNAs.ResultsThrough univariate, multivariate, and least absolute shrinkage and selection operator (LASSO) regression algorithms analyses, we identified 10 lncRNAs. These were then utilized to construct prognostic prediction models, culminating in a risk-scoring signature. Reliability and validity tests demonstrated that the model effectively discerns glioma patients’ prognosis outcomes. We also analyzed the relationship between the risk score and immune characteristics, and identified several drugs that may be effective for high-risk patients. In vitro experiments revealed that LINC02525 could enhances glioma cells’ migration and invasion capacities. Additionally, knocking down LINC02525 was observed to promote glioma cell disulfidptosis.ConclusionThis study delves into disulfidptosis-related lncRNAs in glioma, offering novel insights into glioma therapeutic strategies.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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