Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (May 2025)
Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study
Abstract
Background Sleep is an important determinant of cardiovascular health. We sought to investigate the longitudinal association between sleep duration and incident carotid plaque in a rural Chinese population. Methods This population‐based prospective cohort study included 1004 rural residents (age ≥40 years) who were free of carotid plaque and had no history of clinical stroke and transient ischemic attack at baseline (2017). Incident carotid plaques were detected by carotid ultrasound images at follow‐up (2021). Multivariable Cox regression was used to associate sleep duration with the presence and severity of incident carotid plaques. Restricted cubic splines analyses were conducted to assess dose–response association between sleep duration and incident carotid plaques. Results During the mean follow‐up of 3.95 (SD=0.14) years, 214 (21.3%) of the 1004 participants were found to have incident carotid plaques. A short sleep duration (9 versus 7–9 hours) was not significantly associated with carotid plaques. Restricted cubic splines supported the association of short, but not long, sleep duration with increased risk of incident carotid plaques. Conclusions A short sleep duration is a risk factor for carotid plaques, even among individuals with low‐to‐intermediate cardiovascular disease risk. This suggests that short sleep duration may be a potential target for early interventions to delay carotid atherosclerosis. Registration URL: https://www.chictr.org.cn; Unique Identifier: ChiCTR1800017197.
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