Evaluation of the quality of electrochemical study in the diagnosis of infection of pancreatic cysts

Abstract

The formation of pancreatic cysts is a serious complication of acute pancreatitis, chronic pancreatitis and pancreatic injuries. Joulemetry is an integral method for evaluating the electrochemical properties of biological objects. To date, this method has not been used in the study of the electrochemical properties of the contents of pancreatic cysts. The purpose of this study was to evaluate the effectiveness of electrochemical analysis in the detection of infection in the contents of necrotic pancreatic cysts. An electrochemical study of contents of necrotic pancreatic cysts carried out on 106 patients. Group 1 included 84 patients without signs of infection of pancreatic cysts; group 2 included 22 patients with signs of infection of pancreatic cysts. The electrochemical study was conducted as follows: 10 ml of the contents of a pancreatic cyst was injected into a liquid ˛ow sensor of a joule meter, where it was exposed to a electrical current for a short period of time. The resulting data was analyzed using a diagnostic research complex. During the study of the electrochemical properties of the contents of postnecrotic pancreatic cysts by using joulemetry, it was revealed that the current work in patients of group 1 ranged from 0.92 to 18.31 mkJ (on average 5.86±5.02 mkJ), in patients of group 2 – from 19.01 to 26.3 mkJ (on average 22.32±1.92 mkJ). When evaluating the quality of the joulemetric study in determining the early signs of in˛ammation of the contents of postnecrotic pancreatic cysts, it was proved that the threshold differential diagnostic value of 19.1 mkJ provides 81.8% sensitivity of the proposed method and 80.7% specificity (AUC = 91.3) with a statistically signi˝cant difference in current work (p < 0.001).

Keywords

• postnecrotic pancreatic cysts
• pancreatitis
• joulemetry
• infection
• electrochemical properties