Morphometric evaluation of the study of the features of age remodeling arterial bed of the ovary

Abstract

Summary. To this day, morphologists and clinicians are interested in the features of age remodeling of the organ arterial bed. It should be noted that the age features of ovarian artery remodeling remain poorly understood. The aim of the study – morphometric study of age remodeling of the ovarian arterial bed. Materials and Methods. The structural age remodeling of the ovarian arterial bed of 60 white female rats, which were divided into 2 groups, was morphometrically investigated. Group 1 included 30 animals aged 6 months, group 2 – 30 rats aged 24 months. Animals were euthanized by bloodletting under thiopental anesthesia. Histological microsections were made from the ovaries, on which the outer and inner diameters, thicknesses of the intima, media, adventitia, the height of the endotheliocytes, the diameter of their nuclei, the nuclear-cytoplasmic ratio in these cells, the relative volumes of damaged endotheliocytes, the Wogenvoort, Kernogen indices were determined morphometrically, arteries of small and medium caliber. Quantitative indicators were processed statistically. Results. An age structural reconstruction of the ovarian arteries was established, which was characterized by an increase in the thickness of the media, adventitia, atrophy of the intima, a violation of the relationship between their morphometric parameters, and an increase in the number of damaged endotheliocytes. The identified structural changes dominated in the small-caliber arteries of the organ under study. Conclusions. Age features of remodeling of ovarian arteries are characterized by their thickening, narrowing of the lumen, atrophy of endotheliocytes, increase in media and adventitia thickness, relative volume of damaged endotheliocytes, Wogenvoort index, decrease in Kernogan index. The expressiveness of the age structural reconstruction of the arterial bed of the ovary dominates in small caliber arteries

Keywords

• ovary
• arteries
• morphometry