Serum Resolvin E1 Levels and Its Relationship with Disease Activity in Ulcerative Colitis

Abstract

Background. Resolvins originate from ω-3 PUFA (polyunsaturated fatty acid) precursors and play a role in the resolution of inflammation. The aim of this study was to determine the serum Resolvin E1 levels in patients with ulcerative colitis (UC) and to evaluate the relationship between the serum Resolvin E1 levels and ulcerative colitis disease activity. Methods. In this observational study, serum samples were collected from 51 patients with UC and 30 healthy controls for the determination of Resolvin E1 levels. Firstly, we compared the serum Resolvin E1 levels between the UC patients and the control group. Subsequently, Resolvin E1 levels were analyzed in patients with active UC and UC in remission. Finally, the correlation between Resolvin E1 and C-reactive protein (CRP) and partial Mayo score (p-MS) was analyzed to determine the efficacy of Resolvin E1 in predicting disease activity. Results. Serum Resolvin E1 level was determined in the UC group (3126±1413 ng/ml) and in the control group (2758±1065 ng/ml) (p=0.187). Serum Resolvin E1 levels were determined in patients with active UC (3114±1166 ng/ml) and patients in remission (3132±1520 ng/ml) (p=0.749). In the UC group, a low-grade positive significant association was found between Resolvin E1 and CRP (r=0.303, p=0.031). There was no significant association between Resolvin E1 and partial Mayo score (r=−0.207, p=0.146). Conclusions. There was no sufficient evidence that Resolvin E1 was an appropriate inflammatory marker to determine disease activity in UC.