Nature Communications (May 2020)
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
- Ioanna Ntalla,
- Lu-Chen Weng,
- James H. Cartwright,
- Amelia Weber Hall,
- Gardar Sveinbjornsson,
- Nathan R. Tucker,
- Seung Hoan Choi,
- Mark D. Chaffin,
- Carolina Roselli,
- Michael R. Barnes,
- Borbala Mifsud,
- Helen R. Warren,
- Caroline Hayward,
- Jonathan Marten,
- James J. Cranley,
- Maria Pina Concas,
- Paolo Gasparini,
- Thibaud Boutin,
- Ivana Kolcic,
- Ozren Polasek,
- Igor Rudan,
- Nathalia M. Araujo,
- Maria Fernanda Lima-Costa,
- Antonio Luiz P. Ribeiro,
- Renan P. Souza,
- Eduardo Tarazona-Santos,
- Vilmantas Giedraitis,
- Erik Ingelsson,
- Anubha Mahajan,
- Andrew P. Morris,
- Fabiola Del Greco M,
- Luisa Foco,
- Martin Gögele,
- Andrew A. Hicks,
- James P. Cook,
- Lars Lind,
- Cecilia M. Lindgren,
- Johan Sundström,
- Christopher P. Nelson,
- Muhammad B. Riaz,
- Nilesh J. Samani,
- Gianfranco Sinagra,
- Sheila Ulivi,
- Mika Kähönen,
- Pashupati P. Mishra,
- Nina Mononen,
- Kjell Nikus,
- Mark J. Caulfield,
- Anna Dominiczak,
- Sandosh Padmanabhan,
- May E. Montasser,
- Jeff R. O’Connell,
- Kathleen Ryan,
- Alan R. Shuldiner,
- Stefanie Aeschbacher,
- David Conen,
- Lorenz Risch,
- Sébastien Thériault,
- Nina Hutri-Kähönen,
- Terho Lehtimäki,
- Leo-Pekka Lyytikäinen,
- Olli T. Raitakari,
- Catriona L. K. Barnes,
- Harry Campbell,
- Peter K. Joshi,
- James F. Wilson,
- Aaron Isaacs,
- Jan A. Kors,
- Cornelia M. van Duijn,
- Paul L. Huang,
- Vilmundur Gudnason,
- Tamara B. Harris,
- Lenore J. Launer,
- Albert V. Smith,
- Erwin P. Bottinger,
- Ruth J. F. Loos,
- Girish N. Nadkarni,
- Michael H. Preuss,
- Adolfo Correa,
- Hao Mei,
- James Wilson,
- Thomas Meitinger,
- Martina Müller-Nurasyid,
- Annette Peters,
- Melanie Waldenberger,
- Massimo Mangino,
- Timothy D. Spector,
- Michiel Rienstra,
- Yordi J. van de Vegte,
- Pim van der Harst,
- Niek Verweij,
- Stefan Kääb,
- Katharina Schramm,
- Moritz F. Sinner,
- Konstantin Strauch,
- Michael J. Cutler,
- Diane Fatkin,
- Barry London,
- Morten Olesen,
- Dan M. Roden,
- M. Benjamin Shoemaker,
- J. Gustav Smith,
- Mary L. Biggs,
- Joshua C. Bis,
- Jennifer A. Brody,
- Bruce M. Psaty,
- Kenneth Rice,
- Nona Sotoodehnia,
- Alessandro De Grandi,
- Christian Fuchsberger,
- Cristian Pattaro,
- Peter P. Pramstaller,
- Ian Ford,
- J. Wouter Jukema,
- Peter W. Macfarlane,
- Stella Trompet,
- Marcus Dörr,
- Stephan B. Felix,
- Uwe Völker,
- Stefan Weiss,
- Aki S. Havulinna,
- Antti Jula,
- Katri Sääksjärvi,
- Veikko Salomaa,
- Xiuqing Guo,
- Susan R. Heckbert,
- Henry J. Lin,
- Jerome I. Rotter,
- Kent D. Taylor,
- Jie Yao,
- Renée de Mutsert,
- Arie C. Maan,
- Dennis O. Mook-Kanamori,
- Raymond Noordam,
- Francesco Cucca,
- Jun Ding,
- Edward G. Lakatta,
- Yong Qian,
- Kirill V. Tarasov,
- Daniel Levy,
- Honghuang Lin,
- Christopher H. Newton-Cheh,
- Kathryn L. Lunetta,
- Alison D. Murray,
- David J. Porteous,
- Blair H. Smith,
- Bruno H. Stricker,
- André Uitterlinden,
- Marten E. van den Berg,
- Jeffrey Haessler,
- Rebecca D. Jackson,
- Charles Kooperberg,
- Ulrike Peters,
- Alexander P. Reiner,
- Eric A. Whitsel,
- Alvaro Alonso,
- Dan E. Arking,
- Eric Boerwinkle,
- Georg B. Ehret,
- Elsayed Z. Soliman,
- Christy L. Avery,
- Stephanie M. Gogarten,
- Kathleen F. Kerr,
- Cathy C. Laurie,
- Amanda A. Seyerle,
- Adrienne Stilp,
- Solmaz Assa,
- M. Abdullah Said,
- M. Yldau van der Ende,
- Pier D. Lambiase,
- Michele Orini,
- Julia Ramirez,
- Stefan Van Duijvenboden,
- David O. Arnar,
- Daniel F. Gudbjartsson,
- Hilma Holm,
- Patrick Sulem,
- Gudmar Thorleifsson,
- Rosa B. Thorolfsdottir,
- Unnur Thorsteinsdottir,
- Emelia J. Benjamin,
- Andrew Tinker,
- Kari Stefansson,
- Patrick T. Ellinor,
- Yalda Jamshidi,
- Steven A. Lubitz,
- Patricia B. Munroe
Affiliations
- Ioanna Ntalla
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Lu-Chen Weng
- Cardiovascular Research Center, Massachusetts General Hospital
- James H. Cartwright
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Amelia Weber Hall
- Cardiovascular Research Center, Massachusetts General Hospital
- Gardar Sveinbjornsson
- deCODE genetics/Amgen, Inc.
- Nathan R. Tucker
- Cardiovascular Research Center, Massachusetts General Hospital
- Seung Hoan Choi
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Mark D. Chaffin
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Carolina Roselli
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Michael R. Barnes
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Borbala Mifsud
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Helen R. Warren
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Caroline Hayward
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Jonathan Marten
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- James J. Cranley
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Maria Pina Concas
- Institute for Maternal and Child Health-IRCCS ‘Burlo Garofolo’
- Paolo Gasparini
- Institute for Maternal and Child Health-IRCCS ‘Burlo Garofolo’
- Thibaud Boutin
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Ivana Kolcic
- University of Split School of Medicine
- Ozren Polasek
- University of Split School of Medicine
- Igor Rudan
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Nathalia M. Araujo
- Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte
- Maria Fernanda Lima-Costa
- Rene Rachou Reserch Institute, Oswaldo Cruz Foundation, Belo Horizonte
- Antonio Luiz P. Ribeiro
- Hospital das Clínicas e Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte
- Renan P. Souza
- Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte
- Eduardo Tarazona-Santos
- Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte
- Vilmantas Giedraitis
- Department of Public Health, Geriatrics, Uppsala University
- Erik Ingelsson
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Anubha Mahajan
- Wellcome Centre for Human Genetics, University of Oxford
- Andrew P. Morris
- Wellcome Centre for Human Genetics, University of Oxford
- Fabiola Del Greco M
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Luisa Foco
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Martin Gögele
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Andrew A. Hicks
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- James P. Cook
- Department of Biostatistics, University of Liverpool
- Lars Lind
- Medical Sciences, Uppsala University Hospital
- Cecilia M. Lindgren
- Nuffield Department of Medicine, Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford
- Johan Sundström
- Department of Medical Sciences, Uppsala University
- Christopher P. Nelson
- Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester
- Muhammad B. Riaz
- Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester
- Nilesh J. Samani
- Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester
- Gianfranco Sinagra
- Cardiovascular Department, Azienda Ospedaliera Universitaria Integrata of Trieste
- Sheila Ulivi
- Institute for Maternal and Child Health-IRCCS ‘Burlo Garofolo’
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital
- Pashupati P. Mishra
- Department of Clinical Chemistry, Fimlab Laboratories
- Nina Mononen
- Department of Clinical Chemistry, Fimlab Laboratories
- Kjell Nikus
- Department of Cardiology, Heart Center, Tampere University Hospital
- Mark J. Caulfield
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Anna Dominiczak
- Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Sandosh Padmanabhan
- Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- May E. Montasser
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Jeff R. O’Connell
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Kathleen Ryan
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Alan R. Shuldiner
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Stefanie Aeschbacher
- Cardiology Division, University Hospital
- David Conen
- Cardiology Division, University Hospital
- Lorenz Risch
- Institute of Clinical Chemistry, Inselspital Bern, University Hospital, University of Bern
- Sébastien Thériault
- Population Health Research Institute, McMaster University
- Nina Hutri-Kähönen
- Department of Pediatrics, Tampere University Hospital
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories
- Olli T. Raitakari
- Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
- Catriona L. K. Barnes
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Harry Campbell
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Peter K. Joshi
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- James F. Wilson
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Aaron Isaacs
- CARIM School for Cardiovascular Diseases, Maastricht Center for Systems Biology (MaCSBio), Department of Biochemistry, and Department of Physiology, Maastricht University
- Jan A. Kors
- Department of Medical Informatics Erasmus MC, University Medical Center Rotterdam
- Cornelia M. van Duijn
- Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center
- Paul L. Huang
- Cardiovascular Research Center, Massachusetts General Hospital
- Vilmundur Gudnason
- Icelandic Heart Association
- Tamara B. Harris
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH
- Lenore J. Launer
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH
- Albert V. Smith
- Icelandic Heart Association
- Erwin P. Bottinger
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Ruth J. F. Loos
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Girish N. Nadkarni
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Michael H. Preuss
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Adolfo Correa
- Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center
- Hao Mei
- Department of Data Science, University of Mississippi Medical Center
- James Wilson
- Department of Physiology and Biophysics, University of Mississippi Medical Center
- Thomas Meitinger
- DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance
- Martina Müller-Nurasyid
- DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance
- Annette Peters
- DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance
- Melanie Waldenberger
- DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance
- Massimo Mangino
- Department of Twin Research and Genetic Epidemiology, Kings College London
- Timothy D. Spector
- Department of Twin Research and Genetic Epidemiology, Kings College London
- Michiel Rienstra
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Yordi J. van de Vegte
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Pim van der Harst
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Niek Verweij
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Stefan Kääb
- DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance
- Katharina Schramm
- DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance
- Moritz F. Sinner
- DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance
- Konstantin Strauch
- Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Michael J. Cutler
- Intermountain Heart Institute, Intermountain Medical Center
- Diane Fatkin
- Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute
- Barry London
- Department of Cardiovascular Medicine, University of Iowa
- Morten Olesen
- Laboratory for Molecular Cardiology, Department of Cardiology, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen
- Dan M. Roden
- Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center
- M. Benjamin Shoemaker
- Department of Medicine, Vanderbilt University Medical Center
- J. Gustav Smith
- Department of Cardiology, Clinical Sciences, Wallenberg Center for Molecular Medicine, Lund University Diabetes Center, Lund University and Skane University Hospital
- Mary L. Biggs
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Jennifer A. Brody
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Kenneth Rice
- Department of Biostatistics, University of Washington
- Nona Sotoodehnia
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Alessandro De Grandi
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Christian Fuchsberger
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Cristian Pattaro
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Peter P. Pramstaller
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Ian Ford
- Robertson Center for Biostatistics, University of Glasgow
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Peter W. Macfarlane
- Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Stella Trompet
- Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center
- Marcus Dörr
- DZHK (German Centre for Cardiovascular Research)
- Stephan B. Felix
- DZHK (German Centre for Cardiovascular Research)
- Uwe Völker
- DZHK (German Centre for Cardiovascular Research)
- Stefan Weiss
- DZHK (German Centre for Cardiovascular Research)
- Aki S. Havulinna
- Finnish Institute for Health and Welfare
- Antti Jula
- Finnish Institute for Health and Welfare
- Katri Sääksjärvi
- Finnish Institute for Health and Welfare
- Veikko Salomaa
- Finnish Institute for Health and Welfare
- Xiuqing Guo
- Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Susan R. Heckbert
- Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington
- Henry J. Lin
- Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Kent D. Taylor
- Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Jie Yao
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Renée de Mutsert
- Department of Clinical Epidemiology, Leiden University Medical Center
- Arie C. Maan
- Department of Cardiology, Leiden University Medical Center
- Dennis O. Mook-Kanamori
- Department of Clinical Epidemiology, Leiden University Medical Center
- Raymond Noordam
- Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center
- Francesco Cucca
- Department of Biomedical Sciences, University of Sassari
- Jun Ding
- Laboratory of Genetics and Genomics, NIA/NIH
- Edward G. Lakatta
- Laboratory of Cardiovascular Science, NIA/NIH
- Yong Qian
- Laboratory of Genetics and Genomics, NIA/NIH
- Kirill V. Tarasov
- Laboratory of Cardiovascular Science, NIA/NIH
- Daniel Levy
- Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute
- Honghuang Lin
- National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study
- Christopher H. Newton-Cheh
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Kathryn L. Lunetta
- National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study
- Alison D. Murray
- The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen
- David J. Porteous
- Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital
- Blair H. Smith
- Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee
- Bruno H. Stricker
- Department of Epidemiology Erasmus MC, University Medical Center Rotterdam
- André Uitterlinden
- Human Genotyping Facility Erasmus MC University Medical Center Rotterdam
- Marten E. van den Berg
- Department of Epidemiology Erasmus MC, University Medical Center Rotterdam
- Jeffrey Haessler
- Fred Hutchinson Cancer Research Center, Division of Public Health Sciences
- Rebecca D. Jackson
- Division of Endocrinology, Diabetes and Metabolism, Ohio State University
- Charles Kooperberg
- Fred Hutchinson Cancer Research Center, Division of Public Health Sciences
- Ulrike Peters
- Fred Hutchinson Cancer Research Center, Division of Public Health Sciences
- Alexander P. Reiner
- Fred Hutchinson Cancer Research Center, Division of Public Health Sciences
- Eric A. Whitsel
- Departments of Epidemiology and Medicine, Gillings School of Global Public Health and School of Medicine, University of North Carolina
- Alvaro Alonso
- Department of Epidemiology, Rollins School of Public Health, Emory University
- Dan E. Arking
- McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
- Eric Boerwinkle
- Human Genetics Center, University of Texas Health Science Center at Houston
- Georg B. Ehret
- Cardiology, Geneva University Hospitals
- Elsayed Z. Soliman
- Epidemiological Cardiology Research Center, Wake Forest School of Medicine
- Christy L. Avery
- Department of Epidemiology, University of North Carolina
- Stephanie M. Gogarten
- Department of Biostatistics, University of Washington
- Kathleen F. Kerr
- Department of Biostatistics, University of Washington
- Cathy C. Laurie
- Department of Biostatistics, University of Washington
- Amanda A. Seyerle
- Division of Pharmaceutical Outcomes and Policy, University of North Carolina
- Adrienne Stilp
- Department of Biostatistics, University of Washington
- Solmaz Assa
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- M. Abdullah Said
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- M. Yldau van der Ende
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Pier D. Lambiase
- Barts Heart Centre, St Bartholomews Hospital
- Michele Orini
- Barts Heart Centre, St Bartholomews Hospital
- Julia Ramirez
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Stefan Van Duijvenboden
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- David O. Arnar
- deCODE genetics/Amgen, Inc.
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen, Inc.
- Hilma Holm
- deCODE genetics/Amgen, Inc.
- Patrick Sulem
- deCODE genetics/Amgen, Inc.
- Gudmar Thorleifsson
- deCODE genetics/Amgen, Inc.
- Rosa B. Thorolfsdottir
- deCODE genetics/Amgen, Inc.
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen, Inc.
- Emelia J. Benjamin
- National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study
- Andrew Tinker
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Kari Stefansson
- deCODE genetics/Amgen, Inc.
- Patrick T. Ellinor
- Cardiovascular Research Center, Massachusetts General Hospital
- Yalda Jamshidi
- Genetics Research Centre, Molecular and Clinical Sciences Institute, St George’s, University of London
- Steven A. Lubitz
- Cardiovascular Research Center, Massachusetts General Hospital
- Patricia B. Munroe
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- DOI
- https://doi.org/10.1038/s41467-020-15706-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.
