Folia Medica (Mar 2019)

Evaluation of Teratogenic Activity of Antiepileptic Drug Lamotrigine in Mouse Fetuses

  • Mobini Gholam Reza,
  • Karimi Abbas,
  • Akbari Abolfazl,
  • Rahmani Forouzan

DOI
https://doi.org/10.2478/folmed-2018-0058
Journal volume & issue
Vol. 61, no. 1
pp. 84 – 89

Abstract

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Background: Use of antiepileptic drugs during pregnancy can be associated with an increased risk of teratogenicity as well as congenital abnormalities. However, there are numerous discrepancies to determine whether lamotrigine, as an antiepileptic drug, can significantly induce malformation in newborn infants or not. Thus, the purpose of the study was to evaluate the teratogenic effects of lamotrigine on mouse fetuses.

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