Biophysica (Feb 2023)

The Effectiveness of Suffruticosol B in Treating Lung Cancer by the Laser Trapping Technique

  • Mulugeta S. Goangul,
  • Rance M. Solomon,
  • Daniel L. Devito,
  • Charles A. Brown,
  • James Coopper,
  • Daniel B. Erenso,
  • Ying Gao,
  • Aline Pellizzaro,
  • Jennifer M. Revalee,
  • Horace T. Crogman

DOI
https://doi.org/10.3390/biophysica3010008
Journal volume & issue
Vol. 3, no. 1
pp. 109 – 120

Abstract

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We used laser trapping to study the effects of suffruticosol B on lung cancer cells. Physical and mechanical changes were found to be statistically significant, with a 63.97% increase over untreated cells and a 79.57% increase over untreated cells after treatment for 3 or 6 h, respectively. The treatment affected the internal structure of the cells, with changes in their elastic properties. The cellular responses showed that treatment with suffruticosol B resulted in the decreased proliferation and invasion of cancer cells. These results suggest that the treatment may be useful in preventing or treating lung cancer.

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