Nature Communications (Aug 2020)

Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis

  • Rafael Núñez-Ramírez,
  • Juanjo Huesa,
  • Yolanda Bel,
  • Juan Ferré,
  • Patricia Casino,
  • Ernesto Arias-Palomo

DOI
https://doi.org/10.1038/s41467-020-17758-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Bacillus thuringiensis Vip3 (Vegetative Insecticidal Protein 3) toxins are widely used in biotech crops to control Lepidopteran pests. Here authors present the cryo-EM structures of the protoxin and the protease-activated state of Vip3Aa which shed light on the molecular basis for Vip3 activation.