Modern Aspects of the Surgical Treatment of Children with Idiopathic Thrombocytopenic Purpura

Abstract

The main link in the pathogenesis of ITP is an excessive elimination of platelets in venous sinuses of the spleen. It justifies the splenectomy in this pathology, which increases the immunosuppression, which is caused by earlier courses prednizolonotherapy. A violation of proteinsynthetical detoxifying and liver function plays an essential link in the pathogenesis of postsplenectomic syndrome. It exacerbates immunosuppression. The composition allows saving all the structural elements of viable lymphoid tissue in the spleen for 7 days. Delayed autotransplantation of preserved splenic tissue gives the body a full lymphoid tissue without signs of hyperplasia. Two-moment autotransplantation of preserved splenic tissue in ITP allows to cut short the phenomenon postsplenectomic immunosuppression with normalization of platelet counts in peripheral blood and to avoid disability. The developed medical complex, including splenectomy with followed by a delayed autotransplantation of splenic tissue is technically simple, requires nonexpensive equipment and can be applied in practical public health services in the treatment of children’s ITP

Keywords

• splenectomy
• autotransplantation
• hyposplenism
• purpura
• children