NEUROIMMUNOLOGICAL ASPECTS OF PATHOGENESIS IN CHILDREN’S CEREBRAL PALSY

Abstract

Аbstract. Present review article considers neuroimmunological issues in pathogenesis of infantile cerebral paralysis (ICP). Various factors of immune system and cytokine regulation network (including TNFα, interleukins) have been shown to participate in development of pathological events in patients with periventricular leukomalacia which result into evolving ICP. Selective cytotoxic activity of TNFα was analyzed as a factor in development of continuous chronic process. A role of immunopathological events for development of cytogenetic rearrangements in peripheral blood cells is proposed. (Med. Immunol., 2011, vol. 13, N 2-3, pp 115-120)

Keywords

• infantile cerebral palsy
• periventricular leukomalacia
• neuroimmunologic mechanisms
• tumor necrosis factor alpha
• cytokines