Nature Communications (Oct 2017)

Kif2 localizes to a subdomain of cortical endoplasmic reticulum that drives asymmetric spindle position

  • Vlad Costache,
  • Celine Hebras,
  • Gerard Pruliere,
  • Lydia Besnardeau,
  • Margaux Failla,
  • Richard R. Copley,
  • David Burgess,
  • Janet Chenevert,
  • Alex McDougall

DOI
https://doi.org/10.1038/s41467-017-01048-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Early ascidian embryos have a cortical subdomain of endoplasmic reticulum (ER) that controls asymmetric spindle positioning driving unequal cell division. Here the authors show that the microtubule depolymerase Kif2 is localized to a cortical subdomain of the ER that is involved in asymmetric spindle positioning.