Nature Communications (Apr 2023)
Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19
- Samuel Druzak,
- Elizabeth Iffrig,
- Blaine R. Roberts,
- Tiantian Zhang,
- Kirby S. Fibben,
- Yumiko Sakurai,
- Hans P. Verkerke,
- Christina A. Rostad,
- Ann Chahroudi,
- Frank Schneider,
- Andrew Kam Ho Wong,
- Anne M. Roberts,
- Joshua D. Chandler,
- Susan O. Kim,
- Mario Mosunjac,
- Marina Mosunjac,
- Rachel Geller,
- Igor Albizua,
- Sean R. Stowell,
- Connie M. Arthur,
- Evan J. Anderson,
- Anna A. Ivanova,
- Jun Ahn,
- Xueyun Liu,
- Kristal Maner-Smith,
- Thomas Bowen,
- Mirko Paiardini,
- Steve E. Bosinger,
- John D. Roback,
- Deanna A. Kulpa,
- Guido Silvestri,
- Wilbur A. Lam,
- Eric A. Ortlund,
- Cheryl L. Maier
Affiliations
- Samuel Druzak
- Department of Biochemistry, Emory University School of Medicine
- Elizabeth Iffrig
- Department of Medicine, Emory University School of Medicine
- Blaine R. Roberts
- Department of Biochemistry, Emory University School of Medicine
- Tiantian Zhang
- Emory Integrated Metabolomics and Lipidomics Core, Emory University School of Medicine
- Kirby S. Fibben
- Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Yumiko Sakurai
- Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Hans P. Verkerke
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Christina A. Rostad
- Department of Pediatrics, Emory University School of Medicine
- Ann Chahroudi
- Department of Pediatrics, Emory University School of Medicine
- Frank Schneider
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Andrew Kam Ho Wong
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Anne M. Roberts
- Department of Biochemistry, Emory University School of Medicine
- Joshua D. Chandler
- Department of Pediatrics, Emory University School of Medicine
- Susan O. Kim
- Department of Pediatrics, Emory University School of Medicine
- Mario Mosunjac
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Marina Mosunjac
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Rachel Geller
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Igor Albizua
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Sean R. Stowell
- Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School
- Connie M. Arthur
- Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School
- Evan J. Anderson
- Department of Medicine, Emory University School of Medicine
- Anna A. Ivanova
- Emory Integrated Metabolomics and Lipidomics Core, Emory University School of Medicine
- Jun Ahn
- Emory Integrated Metabolomics and Lipidomics Core, Emory University School of Medicine
- Xueyun Liu
- Emory Integrated Metabolomics and Lipidomics Core, Emory University School of Medicine
- Kristal Maner-Smith
- Emory Integrated Metabolomics and Lipidomics Core, Emory University School of Medicine
- Thomas Bowen
- Emory Integrated Metabolomics and Lipidomics Core, Emory University School of Medicine
- Mirko Paiardini
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Steve E. Bosinger
- Department of Medicine, Emory University School of Medicine
- John D. Roback
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Deanna A. Kulpa
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Guido Silvestri
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- Wilbur A. Lam
- Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Eric A. Ortlund
- Department of Biochemistry, Emory University School of Medicine
- Cheryl L. Maier
- Department of Pathology and Laboratory Medicine, Emory University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-37269-3
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 22
Abstract
In this work, authors take a multiomics and microfluidics-based approach to elucidate the mechanism of endothelial damage in critical illness associated with SARS-CoV-2.
