Association of Dietary Nutrient Intake with Early Age-Related Macular Degeneration in Japanese-Americans
Ayaka Edo,
Yunialthy Dwia Pertiwi,
Kazuyuki Hirooka,
Shun Masuda,
Muhammad Irfan Kamaruddin,
Masahide Yanagi,
Akiko Nagao,
Haruya Ohno,
Masayasu Yoneda,
Yoshiaki Kiuchi
Affiliations
Ayaka Edo
Department of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8551, Japan
Yunialthy Dwia Pertiwi
Department of Microbiology, Faculty of Medicine, Hasanuddin University, Jl. Perintis Kemerdekaan No.KM.10, Tamalanrea Indah, Kec. Tamalanrea, Kota Makassar 90245, Sulawesi Selatan, Indonesia
Kazuyuki Hirooka
Department of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8551, Japan
Shun Masuda
Department of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8551, Japan
Muhammad Irfan Kamaruddin
Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Hasanuddin University Hospital Building A 4th Floor, Perintis Kemerdekaan Street Km.11, Makassar 90245, Sulawesi Selatan, Indonesia
Masahide Yanagi
Hiroshima-Nomura Eye Clinic, 3-1-202, Matsubara-Cho, Minami-Ku, Hiroshima 732-0822, Japan
Akiko Nagao
Division of Nutrient Management, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8551, Japan
Haruya Ohno
Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8551, Japan
Masayasu Yoneda
Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8551, Japan
Yoshiaki Kiuchi
Department of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8551, Japan
Lifestyle factors may be associated with the development of age-related macular degeneration (AMD), in addition to demographic and genetic factors. The purpose of this cross-sectional study is to elucidate the association between nutrient intake and AMD in the Japanese-American population living in Los Angeles. We conducted a medical survey of Japanese immigrants and their descendants living in Los Angeles, including interviews on dietary habits, fundus photography, and physical examinations. Participants were classified into early AMD and control groups on the basis of fundus photographic findings. Consequently, among the 555 participants, 111 (20.0%) were diagnosed with early AMD. There were no late-stage AMD participants. Multivariate logistic regression analysis showed that the intake of animal fat and saturated fatty acids (SFA) was positively associated with early AMD (p for trend = 0.01 for animal fat, p for trend = 0.02 for SFA), and the intake of vegetable fat, total carbohydrate, simple carbohydrate, sugar, and fructose was inversely associated with early AMD (p for trend = 0.04 for vegetable fat, p for trend = 0.046 for carbohydrate, p for trend = 0.03 for simple carbohydrate, p for trend = 0.046 for sugar, p for trend = 0.02). Our findings suggest that excessive animal fat and SFA intake increases the risk for early AMD in Japanese-Americans whose lifestyles have been westernized.
