Progress of research on the role of primary cilia in cartilage degeneration in temporomandibular joint osteoarthritis

Abstract

Temporomandibular joint osteoarthritis (TMJOA) is characterized by progressive cartilage degeneration, subchondral bone remodeling, chronic inflammation in the synovial tissue and osteophyte formation. Chondrocyte apoptosis is one of the main factors of cartilage degeneration. Prevention and treatment of TMJOA can be achieved by inhibiting premature or excessive chondrocyte apoptosis. Primary cilia protruding from the surface of chondrocytes can sense mechanical stimulation and induce chondrocyte differentiation. Studying the role of primary cilia in TMJOA will help us understand the pathogenesis of TMJOA and construct a reasonable and effective treatment strategy.

Keywords

• |temporomandibular joint|osteoarthritis|cartilage degeneration|chondrocyte|primary cilia