POSSIBILITIY OF SHORT-TERM STRESS INFLUENCES IMPLEMENTATION IN BIOLOGICALLY ACTIVE COMPOUNDS SCREENING

Abstract

This work presents the analysis of phobic anxiety behavioral reactions connected with short-term stress influences. We have established that 15 minutes forced swimming reduces locomotory and exploratory activity of animals without any connection with physical exhaustion. Short-term isolation provokes the increase of irrational searching activity connected with spatial disorder and agitation. During this work we have formed an algorithm which allowed fast screening of anxio-lytics and antidepressants

Keywords

• stress
• anxiety
• forced swimming
• isolation
• immobilization
• pre-clinical studies methods.