The Set1 N-terminal domain and Swd2 interact with RNA polymerase II CTD to recruit COMPASS

Hyun Jin Bae; Marion Dubarry; Jongcheol Jeon; Luis M. Soares; Catherine Dargemont; Jaehoon Kim; Vincent Geli; Stephen Buratowski

doi:10.1038/s41467-020-16082-2

Nature Communications (May 2020)

The Set1 N-terminal domain and Swd2 interact with RNA polymerase II CTD to recruit COMPASS

Hyun Jin Bae,
Marion Dubarry,
Jongcheol Jeon,
Luis M. Soares,
Catherine Dargemont,
Jaehoon Kim,
Vincent Geli,
Stephen Buratowski

Affiliations

Hyun Jin Bae: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Marion Dubarry: Cancer Research Center of Marseille (CRCM), U1068 Inserm, UMR7258 CNRS, Aix Marseille University (AMU), Institut Paoli-Calmettes. Equipe labellisée Ligue contre le cancer
Jongcheol Jeon: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Luis M. Soares: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Catherine Dargemont: Institute of Human Genetics, UMR 9002 CNRS
Jaehoon Kim: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Vincent Geli: Cancer Research Center of Marseille (CRCM), U1068 Inserm, UMR7258 CNRS, Aix Marseille University (AMU), Institut Paoli-Calmettes. Equipe labellisée Ligue contre le cancer
Stephen Buratowski: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-16082-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Methylation of histone H3 lysine 4 (H3K4) by Set1/COMPASS occurs co-transcriptionally, and is important for gene regulation. Here the authors provide evidence that the Set1 N-terminal region and the COMPASS subunit Swd2 interact with RNA polymerase II CTD to recruit COMPASS in budding yeast.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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