Nanomaterial-Based Drug Delivery Systems for Ischemic Stroke
Chengting Jiang,
Yang Zhou,
Rong Chen,
Mengjia Yang,
Haimei Zhou,
Zhengxiu Tang,
Hongling Shi,
Dongdong Qin
Affiliations
Chengting Jiang
Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming 650500, China
Yang Zhou
The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China
Rong Chen
School of Basic Medical Science, Yunnan University of Chinese Medicine, Kunming 650500, China
Mengjia Yang
Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming 650500, China
Haimei Zhou
School of Basic Medical Science, Yunnan University of Chinese Medicine, Kunming 650500, China
Zhengxiu Tang
School of Basic Medical Science, Yunnan University of Chinese Medicine, Kunming 650500, China
Hongling Shi
Department of Rehabilitation Medicine, The Affiliated Hospital of Yunnan University, Kunming 650021, China
Dongdong Qin
Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming 650500, China
Ischemic stroke is a leading cause of death and disability in the world. At present, reperfusion therapy and neuroprotective therapy, as guidelines for identifying effective and adjuvant treatment methods, are limited by treatment time windows, drug bioavailability, and side effects. Nanomaterial-based drug delivery systems have the characteristics of extending half-life, increasing bioavailability, targeting drug delivery, controllable drug release, and low toxicity, thus being used in the treatment of ischemic stroke to increase the therapeutic effects of drugs. Therefore, this review provides a comprehensive overview of nanomaterial-based drug delivery systems from nanocarriers, targeting ligands and stimulus factors of drug release, aiming to find the best combination of nanomaterial-based drug delivery systems for ischemic stroke. Finally, future research areas on nanomaterial-based drug delivery systems in ischemic stroke and the implications of the current knowledge for the development of novel treatment for ischemic stroke were identified.
