Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery

F. J. Voskuil; P. J. Steinkamp; T. Zhao; B. van der Vegt; M. Koller; J. J. Doff; Y. Jayalakshmi; J. P. Hartung; J. Gao; B. D. Sumer; M. J. H. Witjes; G. M. van Dam; the SHINE study group

doi:10.1038/s41467-020-16814-4

Nature Communications (Jun 2020)

Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery

F. J. Voskuil,
P. J. Steinkamp,
T. Zhao,
B. van der Vegt,
M. Koller,
J. J. Doff,
Y. Jayalakshmi,
J. P. Hartung,
J. Gao,
B. D. Sumer,
M. J. H. Witjes,
G. M. van Dam,
the SHINE study group

Affiliations

F. J. Voskuil: Department of Oral & Maxillofacial Surgery, University of Groningen, University Medical Center Groningen
P. J. Steinkamp: Departments of Surgery, Nuclear Medicine and Molecular Imaging, Medical Imaging Center Groningen, University of Groningen, University Medical Center Groningen
T. Zhao: OncoNano Medicine Inc.
B. van der Vegt: Department of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen
M. Koller: Departments of Surgery, Nuclear Medicine and Molecular Imaging, Medical Imaging Center Groningen, University of Groningen, University Medical Center Groningen
J. J. Doff: Department of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen
Y. Jayalakshmi: OncoNano Medicine Inc.
J. P. Hartung: JPH Clinical Development
J. Gao: Department of Otolaryngology Head and Neck Surgery, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
B. D. Sumer: Department of Otolaryngology Head and Neck Surgery, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
M. J. H. Witjes: Department of Oral & Maxillofacial Surgery, University of Groningen, University Medical Center Groningen
G. M. van Dam: Departments of Surgery, Nuclear Medicine and Molecular Imaging, Medical Imaging Center Groningen, University of Groningen, University Medical Center Groningen
the SHINE study group

DOI: https://doi.org/10.1038/s41467-020-16814-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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It is well known that the pH of tumor tissue is lower than that of the corresponding normal adjacent tissue. Here, the authors report a clinical trial of a pH activatable nanoparticle for imaging tumours.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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