Nature Communications (Jun 2022)
MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
- Ling Tao,
- Mahmoud A. Mohammad,
- Giorgio Milazzo,
- Myrthala Moreno-Smith,
- Tajhal D. Patel,
- Barry Zorman,
- Andrew Badachhape,
- Blanca E. Hernandez,
- Amber B. Wolf,
- Zihua Zeng,
- Jennifer H. Foster,
- Sara Aloisi,
- Pavel Sumazin,
- Youli Zu,
- John Hicks,
- Ketan B. Ghaghada,
- Nagireddy Putluri,
- Giovanni Perini,
- Cristian Coarfa,
- Eveline Barbieri
Affiliations
- Ling Tao
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- Mahmoud A. Mohammad
- Department of Pediatrics-Nutrition, Baylor College of Medicine
- Giorgio Milazzo
- Department of Pharmacy and Biotechnology, University of Bologna
- Myrthala Moreno-Smith
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- Tajhal D. Patel
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- Barry Zorman
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- Andrew Badachhape
- Department of Radiology, Texas Children’s Hospital, Baylor College of Medicine
- Blanca E. Hernandez
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- Amber B. Wolf
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- Zihua Zeng
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- Jennifer H. Foster
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- Sara Aloisi
- Department of Pharmacy and Biotechnology, University of Bologna
- Pavel Sumazin
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- Youli Zu
- Department of Pathology and Genomic Medicine, Houston Methodist Hospital
- John Hicks
- Department of Pathology and Immunology, Baylor College of Medicine
- Ketan B. Ghaghada
- Department of Radiology, Texas Children’s Hospital, Baylor College of Medicine
- Nagireddy Putluri
- Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Giovanni Perini
- Department of Pharmacy and Biotechnology, University of Bologna
- Cristian Coarfa
- Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Eveline Barbieri
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-31331-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical models.
