High-density lipoprotein cholesterol and nasal colonization of Staphylococcus aureus: results from the 2001–2004 National Health and Nutrition Examination Survey (NHANES)

Abstract

Abstract Background High-density lipoprotein cholesterol (HDL-C) is negatively associated with infectious diseases, but the relationship between HDL-C and nasal colonization of Staphylococcus aureus is unclear. Objective To investigate the relationship between HDL-C and nasal colonization of Staphylococcus aureus. Methods The cross-sectional study included 7731 participants from the 2001–2004 National Health and Nutrition Inspection Survey (NHANES) survey cycle who had complete data. After adjusting demographics and lifestyle, we used multivariate logistic regression to analyze the relationship between HDL-C and nasal colonization of Staphylococcus aureus. We also used restricted cubic splines (RCS) to analyze the nonlinear relationship between HDL-C and nasal colonization of Staphylococcus aureus. All the analyses adjusted the relevant covariates. Results The mean of HDL-C in this study was 1.38 ± 0.64 mmol/L and the colonization rate of nasal colonization of Staphylococcus aureus was 26.2%. Both unadjusted model (OR = 0.71; 95%CI: 0.62–0.80; P 0.05). Conclusions We found that HDL-C was negatively correlated with nasal colonization of Staphylococcus aureus, especially in male, even after adjusting for various variables. These findings provide valuable insights into the development of early intervention strategies in people at high risk of infectious diseases.

Keywords

• HDL-C
• Staphylococcus aureus
• NHANES