Frontiers in Immunology (Jul 2024)

Monocyte distribution width as a promising biomarker for differential diagnosis of chronic hepatitis, cirrhosis, and hepatocellular carcinoma

  • Sheng Lin,
  • Sheng Lin,
  • Sheng Lin,
  • Xinyao Yang,
  • Xinyao Yang,
  • Xin Yang,
  • Xin Yang,
  • Minjie Tang,
  • Minjie Tang,
  • Xiaobao Yao,
  • Xiaobao Yao,
  • Yuchen Ye,
  • Yuchen Ye,
  • Qunfang Huang,
  • Qunfang Huang,
  • Jinlan Huang,
  • Jinlan Huang,
  • Jinlan Huang,
  • Jiejuan Li,
  • Jiejuan Li,
  • Qiang Yi,
  • Qiang Yi,
  • Wennan Wu,
  • Wennan Wu,
  • Wennan Wu,
  • Shiqi Li,
  • Shiqi Li,
  • Yaru Lei,
  • Bin Yang,
  • Bin Yang,
  • Bin Yang,
  • Can Liu,
  • Can Liu,
  • Can Liu,
  • Qishui Ou,
  • Qishui Ou,
  • Qishui Ou,
  • Zhen Xun,
  • Zhen Xun,
  • Zhen Xun

DOI
https://doi.org/10.3389/fimmu.2024.1406671
Journal volume & issue
Vol. 15

Abstract

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ObjectiveWe aimed to investigate the association and diagnostic value of monocyte distribution width (MDW) for chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC).MethodsMDW levels were measured in 483 individuals (103 CHB, 77 LC, 153 HCC, and 150 controls). MDW was detected using UniCel Dx900 for specific cell volume parameters and the distribution of cell volumes.ResultsOur findings revealed a dynamic upward change in MDW levels across different stages of chronic liver disease, from CHB to LC and HCC. In CHB, MDW levels were highest among HBeAg-positive CHB patients and exhibited a negative correlation with HBV markers while positively correlating with ALT levels. In LC, MDW showed a positive association with the pathological progression of LC, demonstrating consistency with CP scores. MDW proved to be equally effective as traditional detection for diagnosing LC. In HCC, MDW was positively correlated with HCC occurrence and development, with higher levels observed in the high MDW group, which also exhibited elevated AFP levels, MELD scores, and 90-day mortality rates. MDW surpassed predictive models in its effectiveness for diagnosing HCC, as well as CHB and LC, with respective areas under the curve of 0.882, 0.978, and 0.973. Furthermore, MDW emerged as an independent predictor of HCC.ConclusionMDW holds significant diagnostic efficacy in identifying CHB, LC, and HCC. These findings suggest that MDW could serve as a promising biomarker for predicting the severity of liver diseases and aid in rational clinical treatment strategies.

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