DEVELOPMENT OF A METHOD FOR THE PREPARATION OF THE NALTREXONE BASE ENCAPSULATED IN POLYMERIC MICROPARTICLES

Abstract

The study is devoted to novel manufacturing method of preparation of polymeric microparticles, loaded by naltrexone base, in flow through regime. Special module construction was developed for providing emulsification in continuous regime. Focusing on production of polymeric microparticles with characteristics, compatible with characteristics of the pharmaceutical Vivitrol and its native analogue, parameters of encapsulation process were defined. An ability of prepared microparticles to prolonged drug release during 28 days was demonstrated.

Keywords

• polymeric microparticles
• long-acting products
• flow-through dispersion
• naltrexone
• vivitrol