Communications Biology (Dec 2020)

Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models

  • Norihiro Nagai,
  • Hirohiko Kawashima,
  • Eriko Toda,
  • Kohei Homma,
  • Hideto Osada,
  • Naymel A. Guzman,
  • Shinsuke Shibata,
  • Yasuo Uchiyama,
  • Hideyuki Okano,
  • Kazuo Tsubota,
  • Yoko Ozawa

DOI
https://doi.org/10.1038/s42003-020-01483-2
Journal volume & issue
Vol. 3, no. 1
pp. 1 – 15

Abstract

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Nagai et al. show that mice fed high-fat diet (HFD) accumulate oxidized low-density lipoprotein in macrophages through the renin–angiotensin system, which impairs visual function. They find that angiotensin II type 1 receptor (AT1R) improves the visual function of HFD mice, suggesting AT1R signaling as a potential therapeutic target for age-related macular degeneration.