Nature Communications (Mar 2023)

Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank

  • Matthias Wuttke,
  • Eva König,
  • Maria-Alexandra Katsara,
  • Holger Kirsten,
  • Saeed Khomeijani Farahani,
  • Alexander Teumer,
  • Yong Li,
  • Martin Lang,
  • Burulca Göcmen,
  • Cristian Pattaro,
  • Dorothee Günzel,
  • Anna Köttgen,
  • Christian Fuchsberger

DOI
https://doi.org/10.1038/s41467-023-36864-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 16

Abstract

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An exome wide association study of UK Biobank data revealed 158 variants and 105 genes significantly associated with kidney function traits and disease. The findings are supported by functional evidence for a previously unreported mutation in CLDN10.