Nature Communications (Aug 2022)
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements
- Peter H. Dixon,
- Adam P. Levine,
- Inês Cebola,
- Melanie M. Y. Chan,
- Aliya S. Amin,
- Anshul Aich,
- Monika Mozere,
- Hannah Maude,
- Alice L. Mitchell,
- Jun Zhang,
- NIHR BioResource,
- Genomics England Research Consortium Collaborators,
- Jenny Chambers,
- Argyro Syngelaki,
- Jennifer Donnelly,
- Sharon Cooley,
- Michael Geary,
- Kypros Nicolaides,
- Malin Thorsell,
- William M. Hague,
- Maria Cecilia Estiu,
- Hanns-Ulrich Marschall,
- Daniel P. Gale,
- Catherine Williamson
Affiliations
- Peter H. Dixon
- Department of Women and Children’s Health, School of Life Course Sciences, King’s College London
- Adam P. Levine
- Department of Renal Medicine, University College London
- Inês Cebola
- Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Melanie M. Y. Chan
- Department of Renal Medicine, University College London
- Aliya S. Amin
- Department of Women and Children’s Health, School of Life Course Sciences, King’s College London
- Anshul Aich
- Department of Renal Medicine, University College London
- Monika Mozere
- Department of Renal Medicine, University College London
- Hannah Maude
- Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Alice L. Mitchell
- Department of Women and Children’s Health, School of Life Course Sciences, King’s College London
- Jun Zhang
- Department of Renal Medicine, University College London
- NIHR BioResource
- NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus
- Genomics England Research Consortium Collaborators
- Genomics England, Queen Mary University of London
- Jenny Chambers
- ICP Support
- Argyro Syngelaki
- Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital
- Jennifer Donnelly
- The Rotunda Hospital
- Sharon Cooley
- The Rotunda Hospital
- Michael Geary
- The Rotunda Hospital
- Kypros Nicolaides
- Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital
- Malin Thorsell
- BB Stockholm, Danderyd Hospital
- William M. Hague
- Robinson Research Institute, The University of Adelaide
- Maria Cecilia Estiu
- Ramón Sardá Mother’s and Children’s Hospital
- Hanns-Ulrich Marschall
- Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg
- Daniel P. Gale
- Department of Renal Medicine, University College London
- Catherine Williamson
- Department of Women and Children’s Health, School of Life Course Sciences, King’s College London
- DOI
- https://doi.org/10.1038/s41467-022-29931-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Investigation of variation in three cohorts has identified multiple genetic signals associated with the pregnancy-specific liver disorder, intrahepatic cholestasis of pregnancy, giving insight into the disease which can cause preterm birth and stillbirth.
