Nature Communications (Jan 2019)
DNA methylation in mice is influenced by genetics as well as sex and life experience
- Sara A. Grimm,
- Takashi Shimbo,
- Motoki Takaku,
- James W. Thomas,
- Scott Auerbach,
- Brian D. Bennett,
- John R. Bucher,
- Adam B. Burkholder,
- Frank Day,
- Ying Du,
- Christopher G. Duncan,
- John E. French,
- Julie F. Foley,
- Jianying Li,
- B. Alex Merrick,
- Raymond R. Tice,
- Tianyuan Wang,
- Xiaojiang Xu,
- NISC Comparative Sequencing Program,
- Pierre R. Bushel,
- David C. Fargo,
- James C. Mullikin,
- Paul A. Wade
Affiliations
- Sara A. Grimm
- Division of Intramural Research, NIEHS
- Takashi Shimbo
- Division of Intramural Research, NIEHS
- Motoki Takaku
- Division of Intramural Research, NIEHS
- James W. Thomas
- NIH Intramural Sequencing Center, National Human Genome Research Institute
- Scott Auerbach
- National Toxicology Program, NIEHS
- Brian D. Bennett
- Division of Intramural Research, NIEHS
- John R. Bucher
- National Toxicology Program, NIEHS
- Adam B. Burkholder
- Division of Intramural Research, NIEHS
- Frank Day
- Division of Intramural Research, NIEHS
- Ying Du
- Division of Intramural Research, NIEHS
- Christopher G. Duncan
- Division of Intramural Research, NIEHS
- John E. French
- National Toxicology Program, NIEHS
- Julie F. Foley
- National Toxicology Program, NIEHS
- Jianying Li
- Division of Intramural Research, NIEHS
- B. Alex Merrick
- National Toxicology Program, NIEHS
- Raymond R. Tice
- National Toxicology Program, NIEHS
- Tianyuan Wang
- Division of Intramural Research, NIEHS
- Xiaojiang Xu
- Division of Intramural Research, NIEHS
- NISC Comparative Sequencing Program
- Pierre R. Bushel
- Division of Intramural Research, NIEHS
- David C. Fargo
- Division of Intramural Research, NIEHS
- James C. Mullikin
- NIH Intramural Sequencing Center, National Human Genome Research Institute
- Paul A. Wade
- Division of Intramural Research, NIEHS
- DOI
- https://doi.org/10.1038/s41467-018-08067-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
DNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across generation and suggest that CpG methylation may serve as an epigenetic record of life events in somatic tissues at loci whose expression is linked to the relevant biology.
