Syntheses, crystal structure, thermal behavior, and anti-tumor activity of three ternary metal complexes with 2-chloro-5-nitrobenzoic acid and heterocyclic compounds

Abstract

Three complexes, namely complex (1), complex (2), and complex (3), were synthesized and characterized by X-ray diffraction, thermogravimetric study, and elemental study. Complex (1) comprises discrete binuclear clusters, where two oxygen atoms of 2-chloro-5-nitrobenzoic acid bridge the two copper atoms. Complex (2) is a six-coordination structure consisting of four nitrogen atoms and two oxygen atoms in 2-chloro-5-nitrobenzoic acid and 1,10-phenanthroline to furnish a twisted octahedron. Complex (3) is a six-coordination structure consisting of four oxygen atoms and two nitrogen atoms from the 2-chloro-5-nitrobenzoic acid, methanol, and 2,2′-dipyridyl to furnish a distorted octahedral geometry. Metal complexes’ anti-tumor activity was also investigated by the MTT assay. Of the complexes tested, complex (1) could induce apoptosis in these A549 lung cancer and Caco-2 colon adenocarcinoma cells and complex (2) could induce apoptosis in Caco-2 colon adenocarcinoma cells. CCDC for complex (1) was 1543354, CCDC for complex (2) was 1546991, and CCDC for complex (3) was 1543417.

Keywords

• metal complexes
• 2-chloro-5-nitrobenzoic acid
• 1,10-phenanthroline
• 2,2′-dipyridyl
• anti-tumor activity